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pentobarbital will decrease the level or result of ethotoin by influencing hepatic enzyme CYP2C9/ten metabolism. Use Caution/Check.pentobarbital increases toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. CYP3A4 inducers may enhance the metabolism of ifosfamide to its active alkylating metabolites.T